In disease states, immune cells must compete for available resources to control tissue homeostasis or mediate protective functions. This is particularly true in cancer, where rapidly proliferating and metabolically dysregulated tumors exert metabolic pressure on cells within the tumor microenvironment. Understanding how immune and non-immune cells respond to these conditions and restrain tumor growth and metastasis is critical for developing new cancer therapies. Often, cancer biologists and immunologists have little crossover, and this presents a significant barrier to furthering knowledge. This interdisciplinary conference will present the latest, cutting-edge research regarding novel and integrated mechanistic underpinnings that lead to cancer progression/regression and metastasis. Specifically, the symposium aims to: 1) Bring together cancer biologists and immunologists who have a common interest in how cellular metabolism influences cell function; 2) Raise awareness of the metabolic intersection between tumor biology and immunology; and 3) Encourage junior researchers to actively participate at this interface. Attendees will leave the conference with a stronger understanding of how metabolism in immune cells and non-immune cells influences cell function in metastasis and the tumor microenvironment. An ultimate goal is that researchers from cancer biology and immunology will, as a result of their interactions, forge new collaborations founded in their mutual appreciation that engagement of particular metabolic pathways shapes cell function and fate.